Pleiotropic Effects of Statins and Their. Clinical Significance. John C. LaRosa, MD. As the clinical trials that established the lipid- lowering beneficial effects of

The gene controlling starch synthesis in pea shows a small degree of pleiotropy. Starch synthesis in pea seeds is controlled by one gene. It has two alleles B and b

Pleiotropy can arise from several distinct but potentially overlapping mechanisms, such as gene Definition of pleiotropy. genetics. : the phenomenon of a single gene influencing two or more distinct phenotypic traits : the quality or state of being pleiotropic In genetics, there's a concept called pleiotropy, which posits that a single gene can influence multiple traits. [Steven] Tanksley suggests there's substantial evidence that at least 2019-07-11 · Pleiotropy is the expression of multiple traits by a single gene.

More example sentences. ‘Many semidwarf mutants have pleiotropic effects on traits other than culm length.’. ‘Many mutants died or showed pleiotropic defects casting doubt on the specificity of their retinal phenotype and were not In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed. It may include adverse effects which are detrimental ones, but is often used to denote additional beneficial effects.. For example, statins are HMG-CoA reductase inhibitors that primarily act by decreasing cholesterol synthesis, but which are believed to have other Video shows what pleiotropic means. of or pertaining to pleiotropy.

Definition of pleiotropy. genetics. : the phenomenon of a single gene influencing two or more distinct phenotypic traits : the quality or state of being pleiotropic In genetics, there's a concept called pleiotropy, which posits that a single gene can influence multiple traits. [Steven] Tanksley suggests there's substantial evidence that at least

pleiotropy · Pleiocene · Pleione · pleiochasium · pleiomorphic. OrdbokPro.se. OrdbokPro.se Progression to stage 2 is defined by dysglycemia or impaired glucose tolerance explains their pleiotropic and some times paradoxical biological activities.

Understanding how these variants impact on disease isn’t easy, as genes are often pleiotropic, meaning that they produce multiple effects in the body. And as the authors pointed out,

the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen. Pleiotropism is a central term in developmental genetics. In pleiotropism, a single gene affects a number of phenotypic traits in the same organism. These pleiotropic effects often seem to be unrelated to each other. The production of diverse effects, especially the production by a single gene of several distinct and seemingly unrelated phenotypic effects.

Sometimes, the gene product may act as a signaling molecule, affecting the functions of many tissues. The gene, which is responsible for the coat color of mice is pleiotropic. Antagonistically pleiotropic genes are the explanation for fitness trade-offs. This means that genes that are pleiotropic control for some beneficial traits and some detrimental traits; thus, if they happen to persist through natural selection, this will prevent organisms from reaching perfection because if they possess the benefits of the gene, they must also possess the imperfections or faults.
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CONTINUE SCROLLING OR CLICK HERE FOR RELATED SLIDESHOW Pleiotropy (drugs) From Wikipedia, the free encyclopedia In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed.
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In pharmacology, pleiotropy includes all of a drug's actions other than those for which the agent was specifically developed. It may include adverse effects which are detrimental ones, but is often used to denote additional beneficial effects.. For example, statins are HMG-CoA reductase inhibitors that primarily act by decreasing cholesterol synthesis, but which are believed to have other

Of or pertaining to pleiotropy. Liknande ord. pleiotropy · Pleiocene · Pleione · pleiochasium · pleiomorphic. OrdbokPro.se. OrdbokPro.se Progression to stage 2 is defined by dysglycemia or impaired glucose tolerance explains their pleiotropic and some times paradoxical biological activities. dessa studiers definition av subocklusion. [10].

NL:pleiotropic. Vertalingen pleiotropic EN>NL. pleiotropic, pleïotroop. Bron: Download IATE, European Union, 2017. Voorbeeldzinnen met `pleiotropic`.

Prognostic significance of faecal eosinophil granule proteins in inflammatory bowel A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Skolastikerna tog senare upp Aristoteles definition och utvecklade den i kristen Senare forskare har reviderat William Sterns metod och definition av ”Pleiotropy across academic subjects at the end of compulsory education” (på engelska). and attention-deficit/hyperactivity disorder localizes pleiotropic loci Journal of Langer, J., Bartolome, L. & Lucas, T. (1990) Meaning Construction in School Pleiospilos · pleiotropic · Pleistarchus · pleistocene · Pleistocene; plenary; plenary to use military means to enforce what is not accepted using other means.

Pleiotropy definition, the phenomenon of one gene being responsible for or affecting more than one phenotypic characteristic. See more. plei·o·trop·ic.