Expression of Lgr5 protein in the human endometrium. Upper img. img 0. Addgene: HR180-LGR5-iCT img. img 1. LGR5 Gene - GeneCards | LGR5 Protein

Rabbit recombinant monoclonal LGR5 antibody [EPR3065Y]. Validated in WB and tested in Mouse, Rat, Human. Cited in 35 publication(s). Independently

It is overexpressed in gastrointestinal tumors and may contribute to tumorigenesis ( Tanese et al., 2008 ). Recently, a group at Kirin Co. reported the development of a mAb (KM4056) Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) as a putative human endometrial stem cell marker. Lgr5 and Bmi1 were co-expressed within the same cells of gastric glands. MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells LGR5 human Fusion Protein 6*His from Proteintech. Produced in E.coli-derived, PET28a, with high quality purity.

We may earn commission from links on this page, but we only recommend products we back. Why trust us? Most people already get enough of this nutrient. 27 Dec 2013 Lgr5 is a membrane protein related to G protein-coupled receptors (GPCR)s whose expression identifies stem cells in multiple tissues and is 5 Sep 2014 Objective Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) has recently been reported to be a marker of cancer stem cells LGR5 (leucine-rich repeat containing G protein-coupled receptor 5) An Orphan GPCR protein, contains large extracellular domain, Stem cell biomarker for small LGR5 (Myc-DDK-tagged)-Human leucine-rich repeat containing G protein- coupled receptor 5 (LGR5) HUGO Gene Nomenclature Committee (HGNC) approved gene symbol report for LGR5 (leucine rich repeat containing G protein-coupled receptor 5) also 26 Jun 2013 Leucine-rich repeat-containing G protein-coupled receptors 4-6 (LGR4-LGR6) are receptors for R-spondins, potent Wnt agonists that exert Detection of Lgr5/GPR49 antibody in HEK293 Human Cell Line Transfected with Leucine‑rich repeat G‑protein‑coupled receptor 5 (Lgr5), also called GPR49, Lgr5 was found to be expressed in the epithelium of the tongue and in the mandible of wild-type embryos. The observed phenotype indicated that Lgr5 is an 12 Jul 2011 LGR5, an orphan receptor of the G protein-coupled receptor (GPCR) superfamily, is specifically expressed in stem cells of the intestinal crypt Validation of Lgr5 as a marker of adult stem cells in the intestine. (A) Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) expression (yellow) is 19 Apr 2017 LGR5, also known as GPR49, is a 100 KD protein.

LGR5, also named as GPR49, GPR67 and HG38, belongs to the G-protein coupled receptor 1 family. It is an orphan receptor. LGR5 is a stem cell marker of the intestinal epithelium and the hair follicule. It is a target gene of Wnt signaling.

2015-01-22 LGR5 (leucine-rich repeat G-protein coupled receptor 5, also known as GPR49) is a member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The LGR subfamily consists of LGR4, LGR5, and LGR6 which are G-protein independent mediators of the R-Spondin effect on Wnt signaling. LGR5 2020-03-16 2019-07-29 LGR5 expression is cell cycle regulated and LGR5 depletion triggers G1 cell-cycle arrest, increased p27 and decreased phosphorylated retinoblastoma protein.

LGR5: Leucine-rich repeat-containing G-protein coupled receptor 5; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle.

UniParc. Sequence archive.

Read more. Reliability scorei. Overall gene reliability score for the subcellular location (s) of the encoded protein (s). Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is an orphan GPCR associated with cancer stem cells in intestinal cancers (Barker et al., 2009 ). It is overexpressed in gastrointestinal tumors and may contribute to tumorigenesis ( Tanese et al., 2008 ). Recently, a group at Kirin Co. reported the development of a mAb (KM4056) Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) as a putative human endometrial stem cell marker. Lgr5 and Bmi1 were co-expressed within the same cells of gastric glands.
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Recent evidence suggests that GPR49 9 Jan 2012 The ProteOn™ XPR36 protein interaction array system enables label-free quantitative analysis of biomolecular interactions in real time using 7 May 2020 In this video we would have a comprehensive understanding about Ras and its function in MAPK signaling pathway. 1 Jan 2019 ER resident proteins ( KDEL sequence). 7,670 views7.6K views. • Jan 1, 2019.
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protein och därmed dämpa cancercellernas tillväxt. – ALK-positiv med titeln”Lgr5 stem cell-based organoids in cancer” där han i en visuellt

Proteomes. Protein sets from fully sequenced genomes. Annotation systems. Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules) Leucine-rich repeat containing G-protein-coupled receptor 5 (LGR5), an intestinal stem cell marker, is known to exhibit tumor suppressor activity in colon cancer, the mechanism of which is not understood. Lgr5 homologues are facultative Wnt receptor components that mediate Wnt signal enhancement by soluble R-spondin proteins. These results will guide future studies towards the application of R-spondins for regenerative purposes of tissues expressing Lgr5 homologues. The colonic epithelial turnover is driven by crypt-base stem cells that express the R-spondin receptor Lgr5.

Tillväxt. TSPAN8/LGR5. Tetraspanin 8/leucine-rich repeat-containing. G protein-coupled receptor 5. Tillväxt. KCNJ11. Potassium inwardly-rectifying channel,.

These results will guide future studies towards the application of R-spondins for regenerative purposes of tissues expressing Lgr5 homologues. Lgr5 (leucine-rich repeat G-protein coupled receptor 5), also called GPR49, is a seven-transmembrane glycoprotein receptor in the Lgr family of cell surface receptors.

LGR5 Protein Molecular Weight & PI Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38) Homo sapiens (Human). The parameters have been computed for the following feature FT CHAIN 22-907 Leucine-rich repeat-containing G-protein Overall reliability score for the subcellular location (s) of the protein (s) in human cells, and summary of the antibodies used for immunostainings.